Assessing the pharmacological potential of selected xanthene derivatives

A convenient and efficient approach toward the synthesis of seven aromatically substituted xanthendiones (1?7) one structurally-related xanthenone (8) through condensation dimedone appropriate aromatic aldehyde is reported. Further, their chemical structure was confirmed by melting points, elemental analysis, FT-IR, 1H, 13C NMR UV-Vis spectroscopic methods. The relationship between pharmacological activity determined empirically using software packages in vitro ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) method. results silico prediction suggested that all investigated compounds possess good oral bioavailability. assay indicate five ability to scavenge ABTS?+ radical cation. Based on comparison IC50 values, found be as follows: 6 > 1 7 2 8. effects solvent dipolarity/polarizability solute solvent-hydrogen-bonding interactions shifts absorption maxima were rationalized means linear solvation energy concepts proposed Kamlet-Taft Catal?n.